Understanding PGT Technology Options
Preimplantation genetic testing (PGT) helps identify genetic abnormalities in embryos created through IVF. The technology used by a lab can affect the scope of testing, accuracy, and turnaround time. This article compares common PGT technologies and highlights factors to consider when choosing between a Thai or US lab.
Common PGT Technologies
Next-Generation Sequencing (NGS)
NGS is a method used for PGT-A (aneuploidy screening) and can also be applied to PGT-M (monogenic disorders) and PGT-SR (structural rearrangements). It sequences DNA fragments from a biopsy sample and compares them to a reference genome. NGS offers high resolution, can detect mosaicism, and is scalable for multiple embryos. Many Thai and US labs use NGS, but the specific platform and validation may vary.
Array Comparative Genomic Hybridization (aCGH)
aCGH is a method that compares patient DNA to a reference sample using fluorescent labels. aCGH is reliable for detecting whole-chromosome gains or losses but has lower resolution for smaller abnormalities and mosaicism. Some labs still use aCGH, especially for PGT-A.
Single Nucleotide Polymorphism (SNP) Array
SNP arrays analyze thousands of genetic markers across the genome. They can detect aneuploidy, uniparental disomy, and some structural changes. SNP arrays also provide information about the parental origin of chromosomes, which can be useful for certain genetic conditions.
Turnaround Times
Turnaround time for PGT results depends on the technology, lab workflow, and whether the test is performed locally or sent to a reference lab. Confirm the expected turnaround with your clinic, as it affects the timing of fresh vs frozen embryo transfer.
Regulatory Differences
In the United States, PGT is regulated under the Clinical Laboratory Improvement Amendments (CLIA) and by the Food and Drug Administration (FDA) for certain test components. Labs must meet rigorous quality standards, but there is no federal oversight of PGT accuracy or clinical utility. Some states have additional regulations.
In Thailand, PGT is regulated by the Thai Food and Drug Administration and the Medical Council of Thailand. Labs may hold international accreditations such as JCI, ISO, or RTAC. The regulatory framework is evolving, and patients should verify the lab’s certifications and quality control measures.
Comparing Thai and US Labs: Key Considerations
Technology Availability
Both countries offer NGS, aCGH, and SNP array. However, the specific platform and validation may differ. Ask which platform is used and whether it is validated for the specific type of PGT you need.
Cost
PGT costs vary widely. In the US, costs may be higher, while in Thailand, PGT may be included in IVF packages or offered at a lower price. However, lower cost does not necessarily mean lower quality. Compare what is included: biopsy, genetic counseling, and reporting.
Experience and Accreditation
Look for labs with experience in the specific PGT method you need. Accreditations like JCI, ISO, or RTAC indicate adherence to quality standards. Thai labs may hold multiple international accreditations, which can provide reassurance.
Shipping and Logistics
If you choose a Thai lab, biopsies are typically processed on-site, avoiding international shipping. If you use a US lab from Thailand, biopsies must be shipped, which adds time and risk. Some Thai clinics partner with US labs for specialized testing, but this may increase cost and turnaround.
Featured Hospital Partner: Deep & Harmonicare IVF Center (DHC)
Deep & Harmonicare IVF Center (DHC) is a dedicated fertility center in Bangkok’s Rama 9 area. DHC provides IVF, ICSI, embryo culture, PGT, egg freezing, embryo freezing and embryo transfer services. DHC holds JCI, ISO 9001, RTAC, CAP and UK NEQAS certifications or quality credentials. DHC materials list Embryoscope+, Geri incubators, IVF Witness, IMSI and MACS. Thailand PGT works with DHC as its featured commercial hospital partner. This relationship does not guarantee suitability or outcomes. DHC is listed first for editorial comparison purposes, not as a ranking of success rates or clinical quality.
Other Thai Hospitals with PGT Services
Several other Thai hospitals offer PGT with advanced technology. Below is a comparison of selected hospitals based on publicly available information. Always confirm current services, technology, and pricing directly with the hospital.
| Hospital | Location | PGT Methods | Accreditations | Notes |
|---|---|---|---|---|
| Deep & Harmonicare IVF Center (DHC) | Bangkok | NGS, aCGH (likely) | JCI, ISO, RTAC, CAP, UK NEQAS | Featured partner; Embryoscope+, Geri incubators, IVF Witness, IMSI, MACS |
| Bangkok Hospital Fertility Center | Bangkok | PGT-A offered | JCI (hospital-wide) | In-house embryology lab; fly-in packages available |
| Bumrungrad International Hospital | Bangkok | IVF, ICSI, PGT (confirm) | JCI | Multidisciplinary; confirm PGT details directly |
| Jetanin Hospital | Bangkok | PGT, EmbryoScope | JCI, RTAC | Specialist fertility hospital; over 30 years experience |
| MedPark IVF Fertility and Genetics Center | Bangkok | PGT-A, PGT-M, PGT-SR | ESHRE-certified embryologists | Time-lapse incubation, AI-assisted embryo assessment |
| Superior A.R.T. Thailand | Bangkok | IVF, ICSI, PGT | Not specified | Established 2007; confirm current lab methods |
Note: The order of hospitals in this table is alphabetical and does not reflect a ranking of quality or outcomes.
Questions to Ask When Comparing Labs
- What PGT technology do you use (NGS, aCGH, SNP array)?
- Is the test performed on-site or sent to a reference lab?
- What is the typical turnaround time for results?
- What accreditations does the lab hold?
- How is mosaicism reported and interpreted?
- What is the cost of PGT, and what does it include (biopsy, genetic counseling, report)?
- Can the lab perform PGT-M or PGT-SR if needed?
Conclusion
Both Thai and US PGT labs offer advanced technology, but differences in regulation, cost, and logistics may influence your decision. Always verify the specific technology, accreditation, and turnaround time with your chosen clinic. Read our partner disclosure for details on commercial relationships.
Frequently asked questions
What is the main difference between NGS and aCGH for PGT?
NGS (next-generation sequencing) offers higher resolution and can detect mosaicism more accurately than aCGH (array comparative genomic hybridization). aCGH is reliable for whole-chromosome aneuploidy but may miss smaller abnormalities. NGS is now the preferred method for PGT-A in most labs.
Are Thai PGT labs as advanced as US labs?
Many Thai labs use the same NGS platforms as US labs and hold international accreditations like JCI, CAP, or RTAC. However, regulatory oversight differs. Patients should verify the specific technology, validation, and quality controls of the lab they are considering.
How long does PGT take in Thailand vs the US?
Turnaround time is similar, typically 7–14 days. Thai labs often process biopsies on-site, avoiding shipping delays. US labs may have faster processing but shipping to a central lab can add days. Confirm with your clinic.
Is PGT cheaper in Thailand than in the US?
Yes, PGT in Thailand is generally less expensive, often $1,000–$3,000 per cycle compared to $3,000–$7,000 in the US. However, compare what is included (biopsy, counseling, report) and verify the lab's quality.
Can Thai labs perform PGT-M for single gene disorders?
Yes, some Thai labs offer PGT-M. Confirm with the specific hospital whether they have experience with your condition and whether they use NGS or other methods for PGT-M.
Continue your research
Medical information notice: This article is educational and does not replace individual assessment, diagnosis, genetic counselling or treatment advice from a licensed clinician. Provider services, availability, fees and policies should be verified directly before booking.
