Understanding Mosaic Embryos: What They Mean for Your IVF Journey in Thailand

If you’ve recently received a mosaic embryo result after preimplantation genetic testing (PGT), you likely have many questions. What does ‘mosaic’ mean? Is the embryo healthy? Can it lead to a successful pregnancy? This guide explains mosaicism in plain English, how it’s reported, and what to consider as you plan your next steps in Thailand.

What Is a Mosaic Embryo?

A mosaic embryo contains a mixture of cells with different chromosomal makeups. Some cells may have the typical number of chromosomes (euploid), while others may have an abnormal number (aneuploid). This is different from a uniformly normal (euploid) embryo or a uniformly abnormal (aneuploid) embryo.

Mosaicism can be detected during PGT, which screens embryos for chromosomal abnormalities before transfer. The degree of mosaicism—the percentage of abnormal cells—can vary, and it is reported as low, moderate, or high.

How Is Mosaicism Reported?

When you receive your PGT results, the embryology lab may categorize embryos as:

• Euploid: normal chromosomal complement
• Aneuploid: abnormal chromosomal complement
• Mosaic: a mix of normal and abnormal cells

Mosaic results are often reported with a percentage, such as ‘20% mosaic’ or ‘40% mosaic.’ The exact reporting method can vary by lab, so it’s important to ask your clinic how they interpret and communicate these results.

What Does a Mosaic Result Mean for Your Embryo?

The presence of mosaicism does not automatically mean the embryo cannot result in a healthy baby. In some cases, mosaic embryos may self-correct during development, or the abnormal cells may be confined to the placenta rather than the baby. However, outcomes vary, and there is no guarantee.

Research suggests that embryos with lower levels of mosaicism may have better outcomes than those with higher levels, but this is not a certainty. Each case is unique, and the decision to transfer a mosaic embryo should be made in close consultation with your physician and a genetic counselor.

Mosaic Embryo Transfer in Bangkok: What to Consider

If you are considering transferring a mosaic embryo in Bangkok, there are several factors to discuss with your clinic:

• Genetic counseling: A genetic counselor can help you understand the specific chromosomal abnormality, the potential risks, and the likelihood of a healthy outcome.
• Further testing: Some clinics may recommend additional testing, such as preimplantation genetic testing for aneuploidy (PGT-A) re-biopsy or prenatal diagnosis after pregnancy is established.
• Clinic policies: Clinics may have different policies regarding the transfer of mosaic embryos. Some may prioritize euploid embryos, while others may consider mosaic embryos for transfer if no euploid embryos are available.
• Legal and ethical considerations: In Thailand, the legal framework around embryo transfer and genetic testing may vary. It’s essential to confirm current regulations with your clinic and relevant authorities.

Mosaic Embryo Results in Thailand: Next Steps

After receiving a mosaic result, you may feel uncertain about what to do next. Here is a step-by-step approach:

1. Schedule a consultation with your fertility specialist to review the results in detail.
2. Request a referral to a genetic counselor who can explain the implications for your specific case.
3. Ask about the lab’s reporting and how they classify mosaicism.
4. Discuss your options, including transferring the mosaic embryo, considering further testing, or using a different embryo.
5. Consider the emotional and practical aspects of your decision, and take the time you need.

Questions to Ask Your Clinic

To make an informed decision, consider asking your clinic the following questions:

• What is the exact percentage of mosaicism in this embryo?
• Which chromosomes are affected, and what are the potential implications?
• What is your clinic’s experience with mosaic embryo transfers?
• What are the success rates for mosaic embryos in your clinic?
• What prenatal testing options are available if I become pregnant?
• Are there any additional costs for genetic counseling or further testing?

Mosaic Embryo Genetic Counseling in Thailand

Genetic counseling is a crucial part of the process when you receive a mosaic result. A genetic counselor can help you understand the scientific aspects, assess the risks, and support you in making a decision that aligns with your values and family goals. In Thailand, genetic counseling services may be available through your fertility clinic or as a standalone service. Be sure to ask about the availability and cost.

Key Takeaways

• A mosaic embryo has a mix of normal and abnormal cells.
• Mosaicism is reported as a percentage, but outcomes vary.
• Transferring a mosaic embryo may be an option, but it requires careful discussion with your doctor and genetic counselor.
• There are no guarantees, and each case is unique.
• Always confirm clinic policies, legal considerations, and costs directly with your provider.

For more information on PGT in Thailand, visit our PGT in Thailand page. You may also find our guides and FAQ sections helpful as you navigate your journey.

Frequently asked questions

Can a mosaic embryo result in a healthy baby?

Yes, in some cases a mosaic embryo can lead to a healthy baby, but outcomes vary. The abnormal cells may not affect the baby, or the embryo may self-correct. However, there is no guarantee, and the decision should be made with your doctor and genetic counselor.

Is a mosaic embryo considered abnormal?

A mosaic embryo is not uniformly normal or abnormal; it has a mix of cells. It is often categorized separately from euploid and aneuploid embryos. The clinical significance depends on the degree and type of mosaicism.

Should I transfer a mosaic embryo if I have no euploid embryos?

This is a decision you should make with your fertility specialist and genetic counselor. Some clinics may offer mosaic embryo transfer as an option, but it depends on the specific situation, the level of mosaicism, and your personal preferences.

What is the difference between a mosaic embryo and an aneuploid embryo?

An aneuploid embryo has an abnormal number of chromosomes in all cells, while a mosaic embryo has a mixture of normal and abnormal cells. Mosaic embryos may have a better chance of developing normally than fully aneuploid embryos, but this is not guaranteed.

Do I need genetic counseling if I have a mosaic embryo?

Yes, genetic counseling is strongly recommended. A genetic counselor can help you understand the specific chromosomal abnormality, the potential risks, and the implications for your pregnancy and child.

Continue your research

• PGT in Thailand overview
• PGT and IVF guides
• Frequently asked questions

Medical information notice: This article is educational and does not replace individual assessment, diagnosis, genetic counselling or treatment advice from a licensed clinician. Provider services, availability, fees and policies should be verified directly before booking.