At a glance

Understand the difference between PGT-A and PGT-M, and learn which questions to ask during your first consultation to prepare for preimplantation genetic testing in Thailand.

Understanding PGT-A and PGT-M

Preimplantation genetic testing (PGT) is a set of techniques used to screen embryos created through IVF for genetic or chromosomal issues before transfer. Two common types are PGT-A (aneuploidy screening) and PGT-M (monogenic disorder testing). PGT-A checks for abnormal numbers of chromosomes, while PGT-M looks for specific inherited genetic conditions. Knowing the difference helps you ask the right questions during your first consultation.

At a Glance: PGT-A vs. PGT-M

  • PGT-A: Screens for chromosomal abnormalities (aneuploidy) that may affect implantation or lead to miscarriage.
  • PGT-M: Tests for specific single-gene disorders, such as cystic fibrosis or Huntington’s disease, when one or both parents carry a known mutation.
  • PGT-SR: A related test for structural rearrangements like translocations, often grouped with PGT-A.

Why the First Consultation Matters

The first consultation is your opportunity to understand whether PGT is appropriate for your situation, what the process involves, and what outcomes you might expect. It is not a commitment to treatment but a chance to gather information and make an informed decision.

Key Questions to Ask About PGT-A

  • What is the purpose of PGT-A, and what does it screen for?
  • How does PGT-A affect the chances of a successful pregnancy?
  • What are the limitations of PGT-A? (e.g., it cannot detect all genetic disorders)
  • Are there alternatives to PGT-A, such as non-invasive screening?

Key Questions to Ask About PGT-M

  • Which specific genetic condition are we testing for, and is the test validated for that condition?
  • How is the genetic mutation identified in the parents?
  • What is the accuracy of PGT-M for our specific mutation?
  • Are there any limitations or risks associated with PGT-M?

General Questions for PGT in Thailand

  • What is the overall process for PGT in Thailand, from initial consultation to embryo transfer?
  • What are the legal and ethical considerations for PGT in Thailand?
  • What are the costs involved, and what does the fee include?
  • What is the timeline for the entire process?
  • What support services are available for international patients?

Preparing for Your Consultation

Before your consultation, gather relevant medical records, including any genetic test results, family history, and previous IVF cycles. Write down your questions and bring a notebook to take notes. Consider whether you want to involve a genetic counselor in the discussion.

Decision-Making Steps

  1. Review your medical history and genetic background.
  2. Understand the difference between PGT-A and PGT-M.
  3. Ask your doctor which test, if any, is recommended for your situation.
  4. Discuss the risks, benefits, and limitations.
  5. Consider alternatives, such as prenatal testing or using donor gametes.
  6. Make a decision based on your values and medical advice.

Next Steps

After your consultation, take time to reflect on the information. If you have further questions, do not hesitate to contact the clinic. You may also want to explore our PGT in Thailand guide for more details, or visit our guides and FAQ sections for additional resources.

Frequently asked questions

What is the main difference between PGT-A and PGT-M?

PGT-A screens embryos for abnormal numbers of chromosomes (aneuploidy), which can affect implantation or lead to miscarriage. PGT-M tests for specific inherited single-gene disorders when parents carry a known mutation.

Can PGT-A detect all genetic disorders?

No, PGT-A only checks for chromosomal abnormalities, not single-gene disorders. For specific inherited conditions, PGT-M is needed.

Is PGT mandatory for all IVF patients?

No, PGT is not mandatory. It is recommended based on individual factors such as maternal age, family history, or previous pregnancy losses. Your doctor can advise if it is appropriate for you.

What questions should I ask about PGT in Thailand?

Ask about the process, legal considerations, costs, timeline, and support for international patients. Also, ask about the clinic's experience with PGT and success rates, though note that success rates vary.

Continue your research

Medical information notice: This article is educational and does not replace individual assessment, diagnosis, genetic counselling or treatment advice from a licensed clinician. Provider services, availability, fees and policies should be verified directly before booking.

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