How to Prepare for a PGT-M Cycle in Thailand: A Step-by-Step Checklist

Preparing for a PGT-M (preimplantation genetic testing for monogenic disorders) cycle in Thailand involves several important steps before you begin IVF. This checklist will guide you through the key preparations, from genetic counseling to coordinating with your clinic and laboratory. Remember that every situation is unique, so always confirm specific requirements with your treating clinic.

At a Glance: Key Preparation Steps

• Confirm your genetic diagnosis and understand the inheritance pattern.
• Undergo genetic counseling to discuss risks and testing options.
• Complete carrier testing for both partners if not already done.
• Choose a PGT-M-capable IVF clinic and laboratory in Thailand.
• Coordinate shipping of genetic samples or test results to the lab.
• Plan your IVF cycle timeline and budget.
• Ask your clinic about specific requirements and timelines.

Step 1: Confirm Your Genetic Diagnosis

Before starting a PGT-M cycle, you need a clear genetic diagnosis of the condition you want to avoid passing on. This usually involves a genetic test that identifies the specific mutation or chromosomal rearrangement. If you have not already had genetic testing, your doctor may recommend carrier screening or diagnostic testing for you and your partner.

It is important to understand the inheritance pattern of the condition (autosomal dominant, autosomal recessive, X-linked, etc.) because this affects the risk of passing it on and the type of PGT-M test needed.

Step 2: Genetic Counseling

Genetic counseling is a crucial step before PGT-M. A genetic counselor or medical geneticist can help you understand:

• The genetic condition and its implications for your family.
• The risk of passing the condition to your children.
• The benefits and limitations of PGT-M.
• Alternative options, such as prenatal diagnosis or using donor gametes.

In Thailand, genetic counseling may be provided by your IVF clinic or through a separate genetics service. Ask your clinic about their counseling process and whether it is included in your treatment package.

Step 3: Carrier Testing for Both Partners

For many genetic conditions, both partners need to be tested to determine the risk of passing on the disorder. Even if you have a known diagnosis, your partner may need carrier testing to confirm the genetic status. This is especially important for autosomal recessive conditions, where both parents must be carriers for the child to be affected.

Carrier testing usually involves a blood or saliva sample. Results can take several weeks, so plan this early in your preparation timeline.

Step 4: Choose a PGT-M-Capable Clinic and Laboratory

Not all IVF clinics in Thailand offer PGT-M. You will need to find a clinic that has experience with PGT-M and works with a laboratory that can perform the genetic analysis. When researching clinics, ask about:

• Their experience with PGT-M for your specific condition.
• The laboratory they use and its accreditation.
• The process for shipping genetic samples or test results.
• The expected timeline from consultation to embryo biopsy and testing.

You may also want to ask about the clinic’s success rates with PGT-M, but keep in mind that success rates can vary and are not a guarantee of outcome.

Step 5: Coordinate with the Laboratory

PGT-M requires a custom genetic test to be developed for your specific mutation. This process, sometimes called ‘probe development’ or ‘test development,’ may take several weeks. Your clinic will coordinate with the laboratory to ensure the test is ready before your IVF cycle begins.

You may need to provide blood samples from both partners and, in some cases, from a child or other family member to help the lab develop the test. Ask your clinic for specific instructions on what samples are needed and how to ship them if you are not in Thailand.

Step 6: Plan Your IVF Cycle Timeline

PGT-M adds extra steps to the IVF process, so your overall timeline will be longer than a standard IVF cycle. Key stages include:

• Ovarian stimulation and egg retrieval.
• Fertilization and embryo culture.
• Embryo biopsy (usually on day 5 or 6).
• Genetic testing of the biopsied cells.
• Transfer of a healthy embryo (if available).

Your clinic will provide a personalized timeline based on your medical history and treatment plan. Be prepared for potential delays, such as the need to repeat a cycle if no embryos are suitable for transfer.

Step 7: Budget and Logistics

PGT-M is more expensive than standard IVF due to the additional genetic testing. Costs may include:

• Genetic counseling and carrier testing.
• IVF treatment.
• Embryo biopsy and genetic analysis.
• Shipping of samples (if applicable).
• Medication and travel expenses.

Ask your clinic for a detailed cost breakdown and what is included in the package. Also consider the logistics of traveling to Thailand, including visa requirements, accommodation, and time off work. Confirm these details with the relevant authorities and your clinic.

Questions to Ask Your Clinic

• What is your experience with PGT-M for my specific condition?
• Which laboratory will perform the genetic testing, and is it accredited?
• How long does it take to develop the custom genetic test?
• What samples do I need to provide, and how should they be shipped?
• What is the expected timeline for the entire PGT-M cycle?
• What are the costs, and what is included?
• What are the limitations and risks of PGT-M?

Next Steps: Your PGT-M Preparation Checklist

• Schedule a genetic counseling session.
• Complete carrier testing for both partners.
• Research and choose a PGT-M-capable clinic in Thailand.
• Coordinate with the clinic and lab on sample shipping and test development.
• Plan your IVF cycle timeline and budget.
• Ask your clinic about specific requirements and timelines.

Preparing for a PGT-M cycle in Thailand requires careful planning and coordination. By following this checklist and working closely with your clinic, you can approach the process with confidence. For more information, explore our PGT in Thailand guide, visit our guides, or check our FAQ section.

Frequently asked questions

What is PGT-M?

PGT-M (preimplantation genetic testing for monogenic disorders) is a test used during IVF to screen embryos for a specific genetic condition caused by a single gene mutation. It helps identify embryos that do not carry the condition, but it does not guarantee a successful pregnancy or a healthy child.

How long does it take to prepare for a PGT-M cycle?

Preparation time can vary. It typically includes genetic counseling, carrier testing, and development of a custom genetic test, which may take several weeks. Your clinic will provide a timeline based on your specific situation.

Do both partners need to be tested for PGT-M?

In many cases, yes. Both partners may need carrier testing to confirm the genetic status, especially for autosomal recessive conditions. Your genetic counselor will advise you on what testing is needed.

Can I do PGT-M if I am not a carrier?

PGT-M is typically used when one or both partners are carriers of a genetic condition or have a family history of a monogenic disorder. If you are not a carrier, PGT-M may not be necessary. Your doctor can help determine if PGT-M is appropriate for you.

What are the limitations of PGT-M?

PGT-M is highly accurate but not 100% perfect. It cannot detect all genetic conditions, and there is a small risk of misdiagnosis. It also does not guarantee that a transferred embryo will implant or result in a live birth. Discuss the limitations with your clinic.

Continue your research

• PGT in Thailand overview
• PGT and IVF guides
• Frequently asked questions

Medical information notice: This article is educational and does not replace individual assessment, diagnosis, genetic counselling or treatment advice from a licensed clinician. Provider services, availability, fees and policies should be verified directly before booking.